BRCA2 anticorps (AA 2336-2478)

N° du produit ABIN7468065

Cet anticorps Souris Monoclonal détecte spécifiquement BRCA2 dans WB, IHC (p) et IHC (fro). Il présente une réactivité envers Humain.

Aperçu rapide pour BRCA2 anticorps (AA 2336-2478) (ABIN7468065)

Antigène: BRCA2 (Breast Cancer 2, Early Onset (BRCA2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp BRCA2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: 5F6

Détail du produit anti-BRCA2 anticorps

Épitope: AA 2336-2478

Réactivité croisée: Humain

Purification: Protein G purified

Immunogène: Amino acids 2336-2478 of human BRCA2 expressed in E. coli. BRCA2-P400.

Isotype: IgG1

Information d'application

Indications d'application: Do not boil samples for longer than two minutes. For WB: Use at a concentration of 1-5 μg/mL. Predicted molecular weight: 380 kDa. Optimal dilutions/concentrations should be determined by the reseracher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, No Preservative

Agent conservateur: Without preservative

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Détails sur BRCA2

Antigène: BRCA2 (Breast Cancer 2, Early Onset (BRCA2))

Autre désignation: BRCA2 DNA repair associated

Sujet:

Synonyms: BRCA2 DNA repair associated , BRCC2 , BROVCA2 , FACD , FAD , FAD1 , FANCD , FANCD1 , GLM3 , PNCA2 , XRCC11

Background: Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, Dec 2008]

Poids moléculaire: 384 kDa

ID gène: 675

UniProt: P51587

Pathways: Réparation de l'ADN, M Phase, Maintenance of Protein Location